The highest efect is 90-120 minutes after administration of the antidote.Enzymes (6) Show 6 proteins Record Informationįomepizole, also known as 4-methylpyrazole or antizol, belongs to the class of organic compounds known as pyrazoles. 1 g), then a maximum of 4 bolus doses, one every 12 hours, then maintenance dose 15 mg/kg, again one every 12 hours. An integral part of the poisoning with methanol or ethylen glycol is administration of folic acid, which accelerates the oxygenation of formic acid and it blocks the accumulation of formic acid in the tissues.įomepizol is administered in infusions diluted by 100 ml 5% glucose or saline solution. It is possible to eliminate Fomepizol with dialysis, it also induces its own metabolization, therefore it is not necessary to monitor its blood level. Fomepizol is being metabolized by system CYP 450 in the liver, its metabolites are excreted in the urine. The advantage of fomepizol is that it is not necessary to monitor the level as it has to be done with ethanol, there is no risk of hypoglycemia and when administered timely, it descreases the need of hemodialysis and it doesn't decrease the activity of the central nervous system.

That leads to decrease of methanol fraction, which would otherwise be transformed into toxic metabolites. Ethanol can be used as a variant for the antidote therapy, because it competes with methanol for an enzyme. Fomepizole is currently not registered in the Czech republic and ordinarily available.

Formic acid damages the retina, optic nerve and basal ganglia, where it accumulates. It blocks the transformation of methanol to formaldehyde, which is toxic and would further transform to formic acid. It is a specific inhibitor of alcoholdehydrogenase. Fomepizole (4-methylpyrazole) is an antidote to methanol or ethylen glycol poisoning.